Our Team

Dr. Tsoumakidou is a board-certified respiratory specialist, group leader at Biomedical Sciences Research Centre (BSRC) Alexander Fleming and associate professor of Physiology at the Medical School of the National and Kapodistrian University of Athens. The overarching goal of her studies has been to decipher the landscape of antigen-presenting cells in immune disorders with the aim of identifying new immunotherapeutic targets and advancing novel therapies. Dr Tsoumakidou is emerging as a leader in the field of cancer immunology for her discovery of a novel subset of lung fibroblasts that present cancer antigens and provide survival signals to lymphocytes, refuting the conventional assumption that fibroblasts are immunosuppressive. She proposes a new concept in cancer immunity whereby anti-tumour CD4 T cells require interaction with antigen-presenting cells in tumor tissues, where tumor antigens reside. Dr Tsoumakidou has published over 30 primary papers and reviews as lead author in high-profile journals (>4000 citations, h-index 27 Source: Google Scholar). She has been the recipient of several awards, among which the Clinical and Research Excellence Award by the Hellenic Thoracic Society. Dr. Tsoumakidou's contributions have been primarily centered in Greece. In 2023 she was awarded a Consolidator grant from the European Research Council (ERC) and in 2025 she founded OncoGenesys, which focuses on the development of immunotherapeutics for cancer patients.
MARIA TSOUMAKIDOU
Founder and President

Nikita Ostrovitsa graduated first-in-class in Chemistry (BSc) from the University of Patras in 2019 and went on to complete an MSc in Drug Discovery and Development at Imperial College London, where he worked in the group of Professor Ed Tate on the design and biological evaluation of macrocyclic peptide inhibitors. In 2025 he obtained his PhD in Organic and Peptide Chemistry at Trinity College Dublin under the supervision of Professor Eoin Scanlan, focusing on innovative synthetic methodologies for peptide cyclisation and modification. His research interests lie in medicinal chemistry, peptide design and the development of new chemical tools for drug discovery, with particular emphasis on applications in cancer. Since 2025, he has been working with OncoGenesys as a Medicinal Chemist, supporting the company’s efforts to translate cutting-edge science into therapeutic advances.
NIKITAS OSTROVITSA
Medicinal Chemist

Dimitrios Koumadorakis obtained an Integrated Master’s degree in Computer Engineering and Informatics from the University of Patras in 2021, graduating with honors. Since February 2023, he has been working at the Biomedical Sciences Research Center "Alexander Fleming" in the group of Professor Maria Tsoumakidou on the cellular and molecular characterization of tumor tissues using scRNA-seq, spatial multi-omics and their associated analytical methodologies. In parallel, he is pursuing a Ph.D. in the field of Informatics. His doctoral research centres on developing machine learning models and computational pipelines for biological data analysis, with a particular interest in cellular heterogeneity, integrative multi-omics, and the design of custom AI architectures. In February 2025, he was awarded an EMBO fellowship and joined the Institute for Computational Biomedicine at Heidelberg University Hospital under the mentorship of Dr. Jovan Tanevski. He has participated in various national and international conferences and has authored eight publications in conference proceedings and peer-reviewed journals. Since 2025, he has served as a bioinformatician at OncoGenesys, where he supports the company’s omics data analytics.
DIMITRIS KOUMADORAKIS
Bioinformatician

Emmanouil Aerakis received his Bachelor’s degree in Molecular
Biology and Genetics from the Democritus University of Thrace in
2018, supported by an IKY fellowship. In 2020, he completed his
Master’s in Molecular and Applied Physiology at the University of
Athens Medical School, graduating with distinction. Since 2021, he
has been pursuing his PhD at the Biomedical Sciences Research
Center "Alexander Fleming" in the group of Professor Maria
Tsoumakidou, supported by an HFRI scholarship. His research focuses
on the spatio-temporal regulation of type I dendritic cells in cancer,
using in vivo and in vitro models, gene-editing techniques, multicolor flow cytometry,
immunofluorescence, and ex vivo human assays. In 2025, he was awarded a Bodossaki
Foundation fellowship and joined the group of Professor Miriam Merad at the Department of
Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai. He has received
awards at national and international conferences and authored two publications. Since 2025,
he has been working with OncoGenesys as a Molecular Biologist supporting target
validation, assay development, and screening strategies for the company’s drug discovery and
screening pipelines.
EMMANOUIL AERAKIS
Molecular Biologist

Alexios N. Matralis holds a B.Sc. in Chemistry from the University of Patras and both an M.Sc. and Ph.D. in Medicinal Chemistry from the University of Athens. He has over fifteen years of research experience in the development of bioactive molecules targeting multifactorial human diseases such as atherosclerosis, type 2 diabetes, cancer, chronic inflammatory disorders, and malaria. Following his Ph.D., he conducted postdoctoral research at McGill University in Montréal, Canada, where he developed a novel series of senescence-inducing agents for pancreatic cancer, which attracted interest from Merck for further development. In 2017, he joined GlaxoSmithKline as a senior researcher, where he contributed to the development of novel fast-acting antimalarial compounds, currently undergoing advanced preclinical studies. In 2018, Alexios joined BSRC “Alexander Fleming” as a Stavros Niarchos Research Fellow where he led research programs focused on small molecule drug discovery targeting fibrosis, cancer, and inflammatory diseases, including an Individual Research Grant from the Hellenic Foundation for Research and Innovation. Since 2025, Alexios serves as Medicinal Chemist Consultant at OncoGenesys, overseeing the development of novel cancer therapeutics.
ALEXIOS MATRALIS
Medicinal Chemist Consultant, External Collaborator

Antreas Afantitis, PhD, MBA is the Founder of NovaMechanics and the Scientific Director of the Entelos Institute. He has a strong scientific background in chem-, bio-, and nanoinformatics, as well as in modeling, simulation, and medicinal and materials chemistry. His work has been published in over 140 original research articles and reviews in international peer-reviewed journals. According to Google Scholar, his h-index exceeds 44, and he is ranked among the world’s top 2% of scientists on the Stanford list. He has successfully coordinated applied drug discovery projects, which have led to the filing of three patents. At NovaMechanics Ltd, he has led the development and implementation of state-of-the-art IT systems—including databases, web services, and custom scientific software—addressing challenges in cheminformatics, bioinformatics, nanoinformatics, modeling, simulation, and big data analysis. He has overseen all R&D activities and product development of the company, including the Isalos Analytics Platform, Enalos+ KNIME nodes, Enalos Cloud Platform, and Enalos Suite. He also participates as Principal Investigator in more than 40 multi-partner international research projects. Since 2025, Antreas has been serving as a Cheminformatics Consultant at OncoGenesys, where he oversees the design of novel small molecules targeting cancer.
ANTREAS AFANTITIS
Cheminformatics Consultant, External Collaborator

Dr. Alex Neagu is an entrepreneur, funding strategist and project designer helping early-stage technology companies secure European financing (dilutive and non-dilutive). With a PhD in Stem Cell Biology and more than a decade of experience in fundraising, Alex blends technical understanding with business acumen to shape competitive proposals, build high-performing consortia, and turn research outcomes into investable, market-ready ventures. His experience in venture capital (INKEF Capital, Amsterdam) is used to advise founders, universities and SMEs (e.g.Golana,Nellow) on opportunity mapping, work-plan architecture, impact and exploitation strategies, and risk-aware budgets, ensuring excellence, credibility, and clear routes to adoption. Alex has led and supported multi-country submissions and grant-funded projects (e.g.BioSusTex), coordinating stakeholders from principal investigators to industrial partners, and aligning objectives, KPIs and governance for measurable results. Since 2025, Alex serves as Operations Manager Consultant at OncoGenesys, overseeing strategic planning and process optimization to support the company’s growth.
ALEX NEAGU
Operations Manager Consultant, External Collaborator
